Innocoll extracts and purifies collagen from either bovine or equine Achilles tendons using a proprietary process which preserves the "triple-helix" molecular structure of Type 1 collagen in the form of fibrils.
This so-called fibrillar collagen (also referred to as "insoluble" collagen) retains its natural physiological functions, namely the wound healing and hemostatic properties1,6
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2. Ranshaw, J.A., Vaughan, P.R. and Werkmeister, J.A., 2001. Applications of collagen in medical devices. Biomedical Engineering: Applications, Basis and Communications, 13(01), pp.16.
3. Parenteau-Bareil, R., Gauvin, R. and Berthod, F., 2010. Collagen-based biomaterials for tissue engineering applications. Materials, 3(3), pp.1863/abstract
4. Anselme, K., Bacques, C., Charriere, G., Hartmann, D.J., Herbage, D. and Garrone, R., 1990. Tissue reaction to subcutaneous implantation of a collagen sponge. A histological, ultrastructural, and immunological study. Journal of biomedical materials research, 24(6), pp.689-703.
5. Ramshaw, J. A. M., Werkmeister, J. A., andGlattauer, V. (1995): ‘Collagen-based biomaterials’,Biotechnol. Genet. Eng. Rev.,13, pp. 336
6. Albu, M.G., Titorencu, I. and Ghica, M.V., 2011. Collagen-based drug delivery systems for tissue engineering. Biomaterials Applications for Nanomedicine, 17, pp.339