ABOUT COLLAGEN

Innocoll has a broad range of treatment solutions, all based on a proprietary collagen-matrix technology that uses Type 1 collagen. Our biocompatible and biodegradable collagen products are engineered for ease of use.

Collagen is the most abundant protein in the human body 1. It has a long history of safe and effective use as a biomaterial in medical technology and offers a series of advantages over synthetic biomaterials 2

  • Collagen is fully biodegradable and bioresorbable via natural pathways3
  • Collagen plays an integral role in the repair and replacement of both soft and hard tissue by providing an extracellular scaffold, stimulating certain growth factors, and propagating tissue granulation4-5
  • Collagen implants and dressings are specifically used to accelerate the natural process of wound healing4
  • Collagen is a natural hemostat and a wide variety of collagen-based products are used in surgery and dentistry to control excessive bleeding or hemorrhaging.

Innocoll extracts and purifies collagen from either bovine or equine Achilles tendons using a proprietary process which preserves the "triple-helix" molecular structure of Type 1 collagen in the form of fibrils.

This so-called fibrillar collagen (also referred to as "insoluble" collagen) retains its natural physiological functions, namely the wound healing and hemostatic properties1,6

References

1. Lee, C.H., Singla, A. and Lee, Y., 2001. Biomedical applications of collagen. International journal of pharmaceutics, 221(1), pg 2

2. Ranshaw, J.A., Vaughan, P.R. and Werkmeister, J.A., 2001. Applications of collagen in medical devices. Biomedical Engineering: Applications, Basis and Communications, 13(01), pp.16.

3. Parenteau-Bareil, R., Gauvin, R. and Berthod, F., 2010. Collagen-based biomaterials for tissue engineering applications. Materials, 3(3), pp.1863/abstract

4. Anselme, K., Bacques, C., Charriere, G., Hartmann, D.J., Herbage, D. and Garrone, R., 1990. Tissue reaction to subcutaneous implantation of a collagen sponge. A histological, ultrastructural, and immunological study. Journal of biomedical materials research, 24(6), pp.689-703.

5. Ramshaw, J. A. M., Werkmeister, J. A., andGlattauer, V. (1995): ‘Collagen-based biomaterials’,Biotechnol. Genet. Eng. Rev.,13, pp. 336

6. Albu, M.G., Titorencu, I. and Ghica, M.V., 2011. Collagen-based drug delivery systems for tissue engineering. Biomaterials Applications for Nanomedicine, 17, pp.339